Clinical Trial Pharmacokinetics, Safety and Clinical Efficacy of CBD Treatment

Pharmacokinetics, Safety and Clinical Efficacy of Cannabidiol Treatment of Osteoarthritic Dogs. July 2018

1-The objectives of the study were to determine basic oral pharmacokinetics and assess safety and analgesic of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA).

2- Single-dose administrations were performed using two different doses of CBD enriched (2 mg and 8 mg/kg) oil. The CBD extraction was reconstituted into an olive oil base. A randomized placebo controlled, veterinarian and owner blinded cross over study was conducted. Each dog received each of the two treatments with a 2-week wash-out period.

3- Twenty-two client owned dogs with clinically and radiographically confirmed evidence of osteoarthritis were recruited for the study. Sixteen of these dogs completed the study. Dogs were removed due to osteosarcoma (placebo oil), gastric torsion (placebo oil), prior aggression issues (CBE oil), kidney insufficiency (CBD oil), reoccurring pododermatitis (placebo oil) and diarrhea (placebo oil).

3- At each visit each dog was evaluated by a veterinarian based on a scoring system as well by its owner (canine brief pain inventory and Hudson activity scale) and blood was collected to repeat complete blood counts and chemistry analysis at weeks 2 and 4 for each treatment.

4- Pharmacokinetics demonstrated that CBD half-life of elimination median was 4.2 hours for the 2 mg dose and 4.2 hours for the 8 mg dose.

5- There were no significant difference in subjective veterinary lameness and weightbearing capacity. There were no observed side effects.

To view this clinical trial: www.frontierin.org/articles/10.3389/fvets.2018.00165/full

Clinical Trial - Veterinarians CBD Knowledge

Us Veterinarians Knowledge, Experience, and Perceptions Regarding the Use of Cannabidiol for Canine Medical Conditions. Published Jan 2019

1 - 2130 participants completed an anonymous online survey. It was created in collaboration with VIN (Veterinary Information Network-an online veterinary community). To evaluate views regarding marijuana and CBD/hemp products.

2 - Any participant who was not in clinical practice (n=26) or did not treat dogs (n=52) were eliminated from the survey.

3 - Participants were asked how often did their clients enquired about CBD products. Totals: rarely (29.2%) monthly (26.4%) never (8%) and daily (7.4%). Clients visiting veterinarians who worked in states that have legalized recreational marijuana were more likely to ask about CBD for their pet as noted in Table 2 chart in the trial.

4 - Participants were asked to identify the specific conditions or diseases for which clients were seeking information. More than one response was allowed. The 4 most common topics were for pain management, anxiety, seizures and storm/fireworks.

5 - Participants were asked about the endorsement of CBD products. Totals: never (44%) rarely (28.8%) sometimes (18.9%) frequently (8%). When asked what was the reason for not advising their clients only half answered the question. Totals: Not enough knowledge about CBD (68.1%) more research is needed (59.57%) it is illegal (48.8%) concerns about toxicity (19.7%)

6 - Perceived impact of CBD products for common canine medical conditions: Decrease’s pain for acute pain - somewhat helpful. Decrease’s pain for chronic pain - somewhat helpful. Reduces anxiety -somewhat helpful. Decrease’s seizures - somewhat helpful. Decrease’s pain for chronic pain – very helpful.

7 - Perception of state organizations’ provision of ‘sufficient guidance’ regarding the use of CBD. Strongly disagree (22%) Disagree (31%) Neutral (24%) Agree (17.3%) Strongly agree (4%)

8 - Overall all participants strongly agree that more toxicity research needs to be done.

9 - 83% Strongly disagree or disagree that CBD should remain a Schedule 1 drug as defined by the DEA. (CBD was removed from the Schedule 1 drug category in January 2020)

10 - 84% Strongly disagree or disagree that Hemp/CBD products for animals should remain illegal at the Federal level.

To view clinical trial: ncbi.nlm.nih.gov/pmc/articles/PMC6338022/

CBD for Pet Allergies? First, what should you know….

Suffering from allergies is enough to get even the happiest pet down. Allergic reactions can cause symptoms such as sneezing, itching and digestive issues. First, it is important to have your pet visit a veterinarian if your pet has diarrhea, is vomiting, or has skin rashes. These issues are urgent and must be immediately addressed by a doctor.

First, what allergies do most pets suffer from?

Allergies are a reaction to their environment or exposure to something and are placed in two categories. Food allergens and environment allergens.

Food allergens … are often misdiagnosed since they share the same symptoms as environmental allergies. It can be particularly confusing when dogs can develop allergies to foods they’ve been eating their whole lives. As pets age, food allergies can develop and a good indicator that your dog is allergic to food rather than something they’ve come into contact with is they will have patches of dry and flaky skin all over their body including the inside of their ears. The next time your pet is itch’s, check to see if the skin is dry and flaky. Dogs with food allergies might also vomit, have diarrhea or have a foul smell in their ears.

Environmental allergens … are a reaction to insects, mites, fragranced detergents, pollen, hair products or even grass. Some of these types of allergies may occur at certain times of the year. The usual symptoms include red inflamed itchy areas of your pet's arms, legs, paws, face, and stomach. This symptom can be all over their body if a hair product such as shampoo was used or if they are frequently wrapped in a favorite blanket that was washed using fragranced detergent.

Most common allergies include: Beef, Dairy, Egg, Poultry, Wheat, Fleas, Pollen, Grass, Insects, Mites, and Dander.

Skin and Stomach issues ... Allergens can cause areas of a dog’s skin to become inflamed and itchy. Your pet will scratch a certain location which can become bloody and infected if left untreated. Vomiting or diarrhea that can’t be explained can be a sign that your dog has an allergy to a food item. Other common symptoms include hives, swelling around the eyes, runny eyes and nose, sneezing when outside, and excessive licking.

How may CBD Oil help with allergies?

CBD oil may provide comfort to experiencing skin pets in a few different ways. A study in 2012 found that CBD oil helps to decrease itchiness in dogs. In 2019. a study found that inflammation was reduced in pets taking CBD oil who had been diagnosed with joint disease. Since a pet can't understand why they're experiencing this discomfort they may become restless or aggressive. Topical and ingested CBD may decrease skin irritation and redness and provide additional calmness to pets. An E-collar may be useful in cases where pets will not stop itching or licking the irritated skin. CBD should be used at add-on therapy to any treatment your pet is currently using.

Now you know all this information, what should you do next?

First learn and decide if CBD may be a good option for your pet. Look for clinical trials, as these resources are often unbiased. If you are uncertain if CBD may interact with current medications or if your pet has certain medical condition contact your veterinarian or a reputable store that can provide guidance from a licensed veterinary professional.

FYI - The 4 most popular products sold on WildLifeRx for pets with skin irritations are:

1. Canna Care CBD by Pet Releaf – A topical product made with Ucuuba butter which encourages the healing of epidermal tissue, Calendula Flower extract which increases healthy cell growth and CBD.

2. Receptra CBD Oil - High potency unflavored extract for picky cats and dogs. A favored product amongst pet CBD users.

3. HolistaPet Calming Chews for Dogs – A 5 mg CBD peanut butter chew to be used throughout the day to increase rest and decrease a pet’s discomfort.

4. Charlottes Web Canine Infused Balm - A topical product made with Tacuma Seed Butter which encourages the repairing of epidermal tissue, Himalayan cedarwood which is a natural insect repellant, and CBD.

Resources:

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment

www.ncbi.nlm.nih.gov/pmc/articles/PMC6065210

Palmieri B, Laurino C, Vadalà M. A therapeutic effect of CBD-enriched ointment in inflammatory skin diseases and cutaneous scars. Clin Ter. 2019 Mar-Apr;170

Petrosino S, Verde R, Vaia M, et al. Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis. J Pharmacol Exp Ther. 2018 Jun;365(3):652-663