Clinical Trial - Veterinarians CBD Knowledge

Us Veterinarians Knowledge, Experience, and Perceptions Regarding the Use of Cannabidiol for Canine Medical Conditions. Published Jan 2019

1 - 2130 participants completed an anonymous online survey. It was created in collaboration with VIN (Veterinary Information Network-an online veterinary community). To evaluate views regarding marijuana and CBD/hemp products.

2 - Any participant who was not in clinical practice (n=26) or did not treat dogs (n=52) were eliminated from the survey.

3 - Participants were asked how often did their clients enquired about CBD products. Totals: rarely (29.2%) monthly (26.4%) never (8%) and daily (7.4%). Clients visiting veterinarians who worked in states that have legalized recreational marijuana were more likely to ask about CBD for their pet as noted in Table 2 chart in the trial.

4 - Participants were asked to identify the specific conditions or diseases for which clients were seeking information. More than one response was allowed. The 4 most common topics were for pain management, anxiety, seizures and storm/fireworks.

5 - Participants were asked about the endorsement of CBD products. Totals: never (44%) rarely (28.8%) sometimes (18.9%) frequently (8%). When asked what was the reason for not advising their clients only half answered the question. Totals: Not enough knowledge about CBD (68.1%) more research is needed (59.57%) it is illegal (48.8%) concerns about toxicity (19.7%)

6 - Perceived impact of CBD products for common canine medical conditions: Decrease’s pain for acute pain - somewhat helpful. Decrease’s pain for chronic pain - somewhat helpful. Reduces anxiety -somewhat helpful. Decrease’s seizures - somewhat helpful. Decrease’s pain for chronic pain – very helpful.

7 - Perception of state organizations’ provision of ‘sufficient guidance’ regarding the use of CBD. Strongly disagree (22%) Disagree (31%) Neutral (24%) Agree (17.3%) Strongly agree (4%)

8 - Overall all participants strongly agree that more toxicity research needs to be done.

9 - 83% Strongly disagree or disagree that CBD should remain a Schedule 1 drug as defined by the DEA. (CBD was removed from the Schedule 1 drug category in January 2020)

10 - 84% Strongly disagree or disagree that Hemp/CBD products for animals should remain illegal at the Federal level.

To view clinical trial: ncbi.nlm.nih.gov/pmc/articles/PMC6338022/

Clinical Trial Baylor Osteoartritis - 2020

Randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis. April 2020

1-The cannabidiol used was provided by MedterraCBD (Irvine, CA), free from THC and the Hemp used was farmed under the strict guidelines of the Department of Agriculture Industrial Hemp pilot program. The CBD used was a 99.99% pure isolate combined with fractionated coconut oil.

2- To increase the effectiveness of the CBD isolate, it was packaged within liposomes, a vehicle delivery system previously shown to improve the uptake of other hydrophobic compounds.

3- Canine veterinary studies were performed with oversight at Baylor College of Medicine. The study population consisted of client owned dogs presented to the Sunset Animal Hospital (Houston, Tx) for evaluation and treatment due to osteoarthritis.

4- Dogs were given either a 20 mg CBD dose, a 50 mg CBD dose or placebo and were evaluated by the owners and the veterinarians.

5- Results were that short-term administration of 50 mg CBD to domestic canines diagnosed with osteoarthritis demonstrated robust and quantifiable anti-inflammatory properties in experimental systems.

To few the clinical trial: www.reserchgate/publication/34098209

CBD for Dogs: What Clinical Trials or Scientific Studies Have Been Performed Recently?

CBD (cannabidiol) for dogs has become one of the most talked-about natural supplements in recent years. And while anecdotal success stories are abundant, what actual scientific studies have been done to confirm the safety and efficacy of CBD?

Much work has still to be done on CBD in both humans and animals, but the results we have so far been promising. In this article, we’ll cover some of the more significant research in both dogs, and other animals. 

Clinical Study #1: Increased Activity and Decreased Inflammation in Arthritic Dogs (Cornell University)

Cornell University researchers found CBD increased activity of dogs suffering from joint discomfort, according to a study published in July of 2018 in Frontiers in Veterinary Science. This clinical study suggests that 2 mg/kg of CBD twice daily can decrease inflammation and increase activity in dogs with decreased mobility. See below for the link to the clinical study.

Clinical Study #2: Significant Improvement in Mobility and Functional Performance (Liberty Leaf)

Released in August of 2018, results from this randomized, placebo-controlled clinical trial demonstrated that dogs with diagnosed osteoarthritis receiving a daily dose of only 0.3 mg per kg of proprietary CBD-infused oil formulation for four weeks showed significantly reduced pain and improved functional performance. See below for the link to the clinical study.

Clinical Study #3: Reduction of Pain & Improved Mobility (Colorado State University)

An April 2020 Colorado State University clinical trial studied the impact of their hemp-derived Cannabidiol (CBD) product on dogs suffering with chronic pain due to osteoarthritis. The 90-day study was overseen by Robin Downing DVM and included 32 dogs that had suffered from chronic arthritic pain for a minimum of 3 months. The study found that the addition of a Full-Spectrum Hemp (CBD) oil resulted in notable benefits (decreased pain scores, improvements in mobility) for 94% of the study dogs. See below for the link to the clinical study.

Clinical Study #4: 89% Reduction in Seizures for Epileptic Dogs (Colorado State University)

A group of researchers from Colorado State University are focused on learning more about CBD oil as a viable treatment for epilepsy in dogs. For 24 weeks, dogs that experience at least two seizures a month will receive either CBD oil treatment or a placebo. Preliminary results released in July of 2018 have shown that a surprising 89% of the dogs studied showed a drop in regular seizures. The study is a double blind, placebo controlled test. See below for the link to the clinical study.

Clinical Study #5: CBD Safety & Delivery Method (Colorado State University)

In 2016, Colorado State University completed work on a pharmacokinetic & safety study of CBD in healthy dogs which could be measurable in the blood. The study suggests that CBD usage in dogs is safe enough to warrant studies in a clinical population. For the study 30 healthy dogs were given 2 different dosages of CBD in 3 different methods of delivery: capsules, oil tincture, and a cream applied on the skin. The results showed that CBD given orally in an oil tincture was most absorbed and bioavailable to the body. See below for the link to the clinical study.

Clinical Study #6: CBD Shows Improvement of Atopic Dermatitis Symptoms (CannaPal Animal Therapeutics)

A study by CannaPal Animal Therapeutics in July of 2020 tested 13 dogs suffering from skin allergies (atopic dermatitis). After the 56 days, Dermatology Specialist Veterinarians assessed the results. Using the CADESI-4 model, they looked at skin lesions and certain areas of the body that are typically affected by atopic dermatitis. The study concluded that dogs using CBD were more likely to see a significant decrease in atopic dermatitis symptoms. The dogs on the CBD formulas had a 51% decrease in CADESI-4 scores, meaning fewer symptoms were present after the study. See below for the link to the clinical study.

Additional Non-Canine Studies on CBD & It’s Effects

CBD for Inflammatory Bowel Syndrome - Human Studies

Multiple studies have shown promising results in alleviating symptoms of inflammatory bowel syndrome in humans. Other studies have suggested CBD can slow the course of the disease, improve symptoms, and increase the efficacy of available drugs for the treatment of disorders such as ulcerative colitis or Crohn’s disease. 

CBD in Treatment-Resistant Epilepsy - Human Studies

Scientists surveyed a group of parents who were interested in sharing information about their children’s experiences with treatment-resistant epilepsy. Nineteen individuals who used cannabidiol-enriched cannabis to treat their children participated. It was found that 84% of the children experienced fewer seizures after taking CBD.

CBD Helps Mice With Acute Pancreatitis

Mice showed evidence that cannabidiol treatment successfully reduces enzyme activity within the pancreas organ tissue. CBD showed anti-inflammatory properties that lead to “improved pathological changes.”

Generalized Social Anxiety Disorder - Human Studies

Researchers administered doses of either CBD oil or a placebo drug to people with a generalized social anxiety disorder to determine possible anxiolytic properties of CBD. They measured cerebral blood flow before and after treatment and found CBD oil to be associated with decreased subjective anxiety.

Self Reported Survey Results on CBD in Dogs: April 2018, 349 Respondents

In April of 2018, iHeartDogs conducted a self-reported survey to 349 respondents who reported to have given CBD to their dogs. The following survey results represent the reasons why CBD was given:

The next question addresses whether the respondents felt CBD helped the condition for which it was given.

In summary, 75.3% of respondents reported that CBD was “Very effective” or “Somewhat effective” at helping their dog’s condition for which is was given.

In conclusion, both the scientific and anecdotal evidence suggests CBD may be a very promising tool in maintaining health and wellness in dogs. If you’d like to learn more about CBD, please visit the resources below.

Citations

Westword: Colorado State University Leading the Way in Veterinary CBD Treatment 

Colorado State University Veterinary Teaching Hospital: Efficacy of Cannabidiol for the Treatment of Epilepsy in Dogs

Colorado State University Veterinary Teaching Hospital: Efficacy of Cannabidiol for the Treatment of Osteoarthritis in Dogs

National Center for Biotechnology Information: Anti-Inflammatory Role of Cannabidiol in Acute Pancreatitis in Mice

National Center for Biotechnology Information: Cannabidiol-Enriched Cannabis Use in Pediatric Treatment-Resistant Epilepsy

National Center for Biotechnology Information: Neural Basis of Anxiolytic Effects of CBD in Generalized Social Anxiety Disorder

Therapeutic Use of Cannabis in Inflammatory Bowel Disease Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs